美国国防部研制秘密武器X-Corp，这是部半人、半机器的实验性武器，利用针状抗生物质的传播媒介进入人的神经系统，进而控制人。但后来武器项目失控，半机器人开始袭击人类，并席卷全球，人类陷入末日境地。一群幸存者小分队肩负起拯救人类的使命……
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