此片根据真实历史事件改编，讲述了日本关东军投降后，残余的731部队骨干成员潜逃并释放鼠疫细菌，造成当地大量百姓伤亡。我军管会搜索队长朝鲁（卢海华饰）、细菌武器的受害者龙棠（乌兰琪琪格饰）与敌人进行殊死较量，最终拔除了这颗危害中国大地的恶魔之牙。
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