《女当家》以墨西哥亿万富翁的权势世界为背景，讲述了一个从龙舌兰酒生意起家的墨西哥商业帝国传奇，讲述了家族多代之间代价高昂的恩怨纷争，以及其中一位家族成员决定与她的家族帮助建立的肮脏系统抗争而引发的斗争。
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